€135

C13910T & G22018A: Genetic Variants Linked to Lactose Tolerance

These two variants are located in the MCM6 gene, which regulates the LCT (lactase) gene, responsible for lactase enzyme production. Lactase is needed to digest lactose, the sugar in milk.

C13910T (rs4988235)

• Found upstream of the LCT gene.

• T allele (C→T change) is associated with lactase persistence, meaning individuals can digest lactose into adulthood.

• C allele is linked to lactase non-persistence (lactose intolerance), where lactase production declines after childhood.

• More common in Europeans and some African populations with a history of dairy consumption.

G22018A (rs182549)

• Another variant in the MCM6 gene, influencing lactase production.

• The A allele (G→A change) is associated with lactose tolerance.

• The G allele is linked to lactose intolerance, leading to symptoms like bloating and diarrhoea after consuming dairy.

Key Takeaways

✅ C13910T & G22018A determine lactase persistence or lactose intolerance.
✅ C and G alleles → Lactose intolerance (reduced lactase production).
✅ T and A alleles → Lactose tolerance (lactase production continues).
✅ Genetic testing helps determine dairy tolerance without needing an elimination diet.